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Statins, inhibitors of 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase, function as inhibitors of cellular and molecular components involved in type I interferon production by Hideki Amuro; Tomoki Ito; Rie Miyamoto; Hiroyuki Sugimoto; Yoshitaro Torii; Yonsu Son; Naoto Nakamichi; Chihiro Yamazaki; Katsuaki Hoshino; Tsuneyasu Kaisho; Yoshio Ozaki; Muneo Inaba; Ryuichi Amakawa; Shirou Fukuhara is a Medicine article available to read on EtoBox.

What is Statins, inhibitors of 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase, function as inhibitors of cellular and molecular components involved in type I interferon production about?

## Abstract ## Objective Statins, which are used as cholesterol‐lowering agents, have pleiotropic immunomodulatory properties. Although beneficial effects of statins have been reported in autoimmune diseases, the mechanisms of these immunomodulatory effects are still poorly understood. Type I interferons (IFNs) and plasmacytoid dendritic cells (PDCs) represent key molecular and cellular pathogenic components in autoimmune diseases such as systemic lupus erythematosus (SLE). Therefore, PDCs may be a specific target of statins in therapeutic strategies against SLE. This study was undertaken to investigate the immunomodulatory mechanisms of statins that target the IFN response in PDCs. ## Methods We isolated human blood PDCs by flow cytometry and examined the effects of simvastatin and pitavastatin on PDC activation, IFNα production, and intracellular signaling. ## Results Statins inhibited IFNα production profoundly and tumor necrosis factor α production modestly in human PDCs in response to Toll‐like receptor ligands. The inhibitory effect on IFNα production was reversed by geranylgeranyl pyrophosphate and was mimicked by either geranylgeranyl transferase inhibitor or Rho kinase inh

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Author

Hideki Amuro; Tomoki Ito; Rie Miyamoto; Hiroyuki Sugimoto; Yoshitaro Torii; Yonsu Son; Naoto Nakamichi; Chihiro Yamazaki; Katsuaki Hoshino; Tsuneyasu Kaisho; Yoshio Ozaki; Muneo Inaba; Ryuichi Amakawa; Shirou Fukuhara

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0004-3591)

Published

2010

Language

EN

Field

Medicine (Health Sciences)