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Nrf2 signaling in diabetic nephropathy, cardiomyopathy and neuropathy: Therapeutic targeting, challenges and future prospective by Mehrdad Hashemi; Mohammad Arad Zandieh; Setayesh Ziaolhagh; Sarah Mojtabavi; Farzaneh Hasani Sadi; Zeinab Khazaei Koohpar; Maryam Ghanbarirad; Arvin Haghighatfard; Mitra Behroozaghdam; Ramin Khorrami; Noushin Nabavi; Jun Ren; Russel J. Reiter; Shokooh Salimimoghadam; Mohsen Rashidi; Kiavash Hushmandi; Afshin Taheriazam; Maliheh Entezari is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Nrf2 signaling in diabetic nephropathy, cardiomyopathy and neuropathy: Therapeutic targeting, challenges and future prospective about?

Western lifestyle contributes to an overt increase in the prevalence of metabolic anomalies including diabetes mellitus (DM) and obesity. Prevalence of DM is rapidly growing worldwide, affecting many individuals in both developing and developed countries. DM is correlated with the onset and development of complications with diabetic nephropathy (DN), diabetic cardiomyopathy (DC) and diabetic neuropathy being the most devastating pathological events. On the other hand, Nrf2 is a regulator for redox balance in cells and accounts for activation of antioxidant enzymes. Dysregulation of Nrf2 signaling has been shown in various human diseases such as DM. This review focuses on the role Nrf2 signaling in major diabetic complications and targeting Nrf2 for treatment of this disease. These three complications share similarities including the presence of oxidative stress, inflammation and fibrosis. Onset and development of fibrosis impairs organ function, while oxidative stress and inflammation can evoke damage to cells. Activation of Nrf2 signaling significantly dampens inflammation and oxidative damage, and is beneficial in retarding interstitial fibrosis in diabetic complications. SIRT1 a

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Author

Mehrdad Hashemi; Mohammad Arad Zandieh; Setayesh Ziaolhagh; Sarah Mojtabavi; Farzaneh Hasani Sadi; Zeinab Khazaei Koohpar; Maryam Ghanbarirad; Arvin Haghighatfard; Mitra Behroozaghdam; Ramin Khorrami; Noushin Nabavi; Jun Ren; Russel J. Reiter; Shokooh Salimimoghadam; Mohsen Rashidi; Kiavash Hushmandi; Afshin Taheriazam; Maliheh Entezari

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)