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Lung Recruitment Improves the Efficacy of Intubation-Surfactant-Extubation Treatment for Respiratory Distress Syndrome in Preterm Neonates, A Randomized Controlled Trial by Yong Yang; Wenkang Yan; MinYi Ruan; Lan Zhang; Jinzhen Su; Haohui Deng; Minxu Li is a scholarly article available to read on EtoBox.

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## Abstract Background: Lung recruitment is a maneuver in preterm neonates at birth, which may decrease the length of intubation. This study aimed to compare the therapeutic efficacy of lung recruitment plus intubation-surfactant-extubation (INSURE) procedure and INSURE alone for the preterm neonates with respiratory distress syndrome.Methods: A total of 184 preterm neonates with respiratory distress syndrome from 2017 to 2019 were enrolled and randomized into the lung recruitment group receiving lung recruitment (25 cm H~2~O for 15 seconds) plus INSURE and the control group receiving INSURE only. The primary outcome was the need for mechanical ventilation (MV) within 72 h after extubation. The secondary outcomes include the duration of intubation, noninvasive ventilation, total oxygen therapy, hospitalization, and other complications.Results: Compared to the control group, the lung recruitment group had a significantly lower proportion of preterm neonates need for MV within 72 h after extubation (23% vs. 38%, P=0.025) and pulmonary surfactant administration, as well as shorter the MV duration. Multivariate logistic regression analysis demonstrated that the control group had a 2.17

Author

Yong Yang; Wenkang Yan; MinYi Ruan; Lan Zhang; Jinzhen Su; Haohui Deng; Minxu Li

Publisher

Research Square Platform LLC

Published

2021

Language

EN