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Can I read Incorporating Advances in Molecular Pathology Into Brain Tumor Diagnostics on EtoBox?
Incorporating Advances in Molecular Pathology Into Brain Tumor Diagnostics by José E. Velázquez Vega; Daniel J. Brat is a Medicine article available to read on EtoBox.
What is Incorporating Advances in Molecular Pathology Into Brain Tumor Diagnostics about?
Recent advances in molecular pathology have reshaped the practice of brain tumor diagnostics. The classification of gliomas has been restructured with the discovery of isocitrate dehydrogenase (IDH) 1/2 mutations in the vast majority of lower grade infiltrating gliomas and secondary glioblastomas (GBM), with IDH-mutant astrocytomas further characterized by TP53 and ATRX mutations. Whole-arm 1p/19q codeletion in conjunction with IDH mutations now define oligodendrogliomas, which are also enriched for CIC, FUBP1, PI3K, NOTCH1, and TERT-p mutations. IDH-wild-type (wt) infiltrating astrocytomas are mostly primary GBMs and are characterized by EGFR, PTEN, TP53, NF1, RB1, PDGFRA, and CDKN2A/B alterations, TERT-p mutations, and characteristic copy number alterations including gains of chromosome 7 and losses of 10. Other clinically and genetically distinct infiltrating astrocytomas include the aggressive H3K27M-mutant midline gliomas, and smaller subsets that occur in the setting of NF1 or have BRAF V600E mutations. Low-grade pediatric gliomas are both genetically and biologically distinct from their adult counterparts and often harbor a single driver event often involving BRAF, FGFR1, or
Who reads Incorporating Advances in Molecular Pathology Into Brain Tumor Diagnostics?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- José E. Velázquez Vega; Daniel J. Brat
- Published
- 2018
- Language
- EN
- Field
- Medicine (Health Sciences)