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Focused ultrasound-mediated suppression of chemically-induced acute epileptic EEG activity by Byoung-Kyong Min; Alexander Bystritsky; Kwang-Ik Jung; Krisztina Fischer; Yongzhi Zhang; Lee-So Maeng; Sang In Park; Yong-An Chung; Ferenc A Jolesz; Seung-Schik Yoo is a Neuroscience article available to read on EtoBox.

What is Focused ultrasound-mediated suppression of chemically-induced acute epileptic EEG activity about?

## Background Epilepsy is a common neurological disorder, which is attributed to uncontrollable abnormal hyper-excitability of neurons. We investigated the feasibility of using low-intensity, pulsed radiation of focused ultrasound (FUS) to non-invasively suppress epileptic activity in an animal model (rat), which was induced by the intraperitonial injection of pentylenetetrazol (PTZ). ## Results After the onset of induced seizures, FUS was transcranially administered to the brain twice for three minutes each while undergoing electroencephalographic (EEG) monitoring. An air-backed, spherical segment ultrasound transducer (diameter: 6 cm; radius-of-curvature: 7 cm) operating at a fundamental frequency of 690 KHz was used to deliver a train of 0.5 msec-long pulses of sonication at a repetitive rate of 100 Hz to the thalamic areas of the brain. The acoustic intensity (130 mW/cm^2^) used in the experiment was sufficiently within the range of safety guidelines for the clinical ultrasound imaging. The occurrence of epileptic EEG bursts from epilepsy-induced rats significantly decreased after sonication when it was compared to the pre-sonication epileptic state. The PTZ-induced control gro

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Author

Byoung-Kyong Min; Alexander Bystritsky; Kwang-Ik Jung; Krisztina Fischer; Yongzhi Zhang; Lee-So Maeng; Sang In Park; Yong-An Chung; Ferenc A Jolesz; Seung-Schik Yoo

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2000-; Springer Science and Business Media LLC (ISSN 1471-2202)

Published

2011

Language

EN

Field

Neuroscience (Life Sciences)