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Can I read 143P Clinical outcomes of systemic therapy for hemodialysis patients with metastatic renal cell carcinoma on EtoBox?
143P Clinical outcomes of systemic therapy for hemodialysis patients with metastatic renal cell carcinoma by S. Iwasa; R. Mizuno; Y. Yasumizu; N. Tanaka; T. Takeda; K. Matsumoto; S. Morita; T. Kosaka; H. Asanuma; M. Oya is a Medicine article available to read on EtoBox.
What is 143P Clinical outcomes of systemic therapy for hemodialysis patients with metastatic renal cell carcinoma about?
Background: Combination immunotherapy with an anti-PD-1 inhibitor and an anti-CTLA-4 inhibitor is used as first-line therapy in metastatic renal cell carcinoma (mRCC). While providing the benefit of a certain population of long-term responders, the frequency of immune-related adverse events (irAEs) is known to be high with the combination therapy. Thus, predictive biomarkers of irAEs could help guide treatment strategies.Methods: We performed a retrospective review of patients with mRCC treated with nivolumab plus ipilimumab from multiple centers between September 2018 and February 2021. We investigated clinical and laboratory findings, including age, sex, absolute eosinophil count, neutrophil-to-lymphocyte ratio (NLR), lymphocyte-tomonocyte ratio (LMR) and C-reactive protein (CRP) level at the baseline, for their association with the occurrence of irAEs using multivariate analyses. In addition, we evaluated the relationship between the occurrence of irAEs and the fold change of CRP and absolute eosinophil count from the baseline to 3 weeks after the initiation of ICIs.Results: A total of 131 patients were included. The median age was 67 years (range 28-87 years), and 92 patients w
Who reads 143P Clinical outcomes of systemic therapy for hemodialysis patients with metastatic renal cell carcinoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- S. Iwasa; R. Mizuno; Y. Yasumizu; N. Tanaka; T. Takeda; K. Matsumoto; S. Morita; T. Kosaka; H. Asanuma; M. Oya
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)