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Can I read Tunable Conductive Hydrogel Scaffolds for Neural Cell Differentiation on EtoBox?
Tunable Conductive Hydrogel Scaffolds for Neural Cell Differentiation by Christina M. Tringides; Marjolaine Boulingre; Andrew Khalil; Tenzin Lungjangwa; Rudolf Jaenisch; David J. Mooney is a Engineering article available to read on EtoBox.
What is Tunable Conductive Hydrogel Scaffolds for Neural Cell Differentiation about?
## Abstract Multielectrode arrays would benefit from intimate engagement with neural cells, but typical arrays do not present a physical environment that mimics that of neural tissues. It is hypothesized that a porous, conductive hydrogel scaffold with appropriate mechanical and conductive properties could support neural cells in 3D, while tunable electrical and mechanical properties could modulate the growth and differentiation of the cellular networks. By incorporating carbon nanomaterials into an alginate hydrogel matrix, and then freeze‐drying the formulations, scaffolds which mimic neural tissue properties are formed. Neural progenitor cells (NPCs) incorporated in the scaffolds form neurite networks which span the material in 3D and differentiate into astrocytes and myelinating oligodendrocytes. Viscoelastic and more conductive scaffolds produce more dense neurite networks, with an increased percentage of astrocytes and higher myelination. Application of exogenous electrical stimulation to the scaffolds increases the percentage of astrocytes and the supporting cells localize differently with the surrounding neurons. The tunable biomaterial scaffolds can support neural cocultur
Who reads Tunable Conductive Hydrogel Scaffolds for Neural Cell Differentiation?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Christina M. Tringides; Marjolaine Boulingre; Andrew Khalil; Tenzin Lungjangwa; Rudolf Jaenisch; David J. Mooney
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Engineering (Physical Sciences)