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Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice by Yu Lan; Rosemary C. Ryan; Zunyi Zhang; Steven A. Bullard; Jeffrey O. Bush; Kathleen M. Maltby; Andrew C. Lidral; Rulang Jiang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice about?
## Abstract Cleft lip with or without cleft palate (CLP) is the most common craniofacial birth defect in humans. Recently, mutations in the __WNT3__ and __Wnt9b__ genes, encoding two members of the Wnt family of signaling molecules, were found associated with CLP in human and mice, respectively. To investigate whether Wnt3 and Wnt9b directly regulate facial development, we analyzed their developmental expression patterns and found that both __Wnt3__ and __Wnt9b__ are expressed in the facial ectoderm at critical stages of midfacial morphogenesis during mouse embryogenesis. Whereas __Wnt3__ mRNA is mainly expressed in the maxillary and medial nasal ectoderm, __Wnt9b__ mRNA is expressed in maxillary, medial nasal, and lateral nasal ectoderm. During lip fusion, __Wnt9b__, but not __Wnt3__, is expressed in the epithelial seam between the fusing medial and lateral nasal processes. Furthermore, we found that expression of TOPGAL, a transgenic reporter of activation of canonical Wnt signaling pathway, is specifically activated in the distal regions of the medial nasal, lateral nasal, and maxillary processes prior to lip fusion. During lip fusion, the epithelial seam between the medial and
Who reads Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yu Lan; Rosemary C. Ryan; Zunyi Zhang; Steven A. Bullard; Jeffrey O. Bush; Kathleen M. Maltby; Andrew C. Lidral; Rulang Jiang
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1058-8388)
- Published
- 2006
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)