Can I read EP149/#657 Prospective analysis of learning curve in robotic assisted type-I extrafascial pan-hysterectomy with pelvic and paraaortic lymphadenectomy for endometrial cancer in an indian tertiary care center on EtoBox?

EP149/#657 Prospective analysis of learning curve in robotic assisted type-I extrafascial pan-hysterectomy with pelvic and paraaortic lymphadenectomy for endometrial cancer in an indian tertiary care center by Elroy Saldanha; Sp Somashekhar; Ashwin Rajagopal; Rohit Kumar is a scholarly article available to read on EtoBox.

What is EP149/#657 Prospective analysis of learning curve in robotic assisted type-I extrafascial pan-hysterectomy with pelvic and paraaortic lymphadenectomy for endometrial cancer in an indian tertiary care center about?

Objectives NR2F6 (nuclear receptor subfamily 2 group F member 6, also called Ear-2) is known to be an orphan nuclear receptor being an intracellular immune checkpoint in effector T cells. It might play an essential role for tumor development and growth. Therefore, the prognostic impact of NR2F6 in endometrial cancer is evaluated in this study. Methods Expression analysis of NR2F6 in 142 endometrial cancer patients was performed by immunohistochemistry. Staining intensity of tumor cells was computerized assessed semi-quantitatively, and results were correlated with clinicopathological characteristics and survival. Results 46 of 117 evaluable samples (39.3 %) showed an overexpression of NR2F6, leading to an improvement of the overall (OS) and disease-free survival (DFS). In NR2F6 positive patients, the mean OS was 156.6 months (95% confidence interval (CI): 142.4 -170.8) compared to 105.8 months in NR2F6 negative patients (95% CI: 85.6 -125.9; p = 0.025). The disease-free survival differed by 58.4 months (156 months (95% CI: 142.2 -169.9) vs. 97.6 months (95% CI: 74.7 -120.6), p = 0.004). Furthermore, we found significant associations between NR2F6 positivity, MMR status, and PD1 sta

Author

Elroy Saldanha; Sp Somashekhar; Ashwin Rajagopal; Rohit Kumar

Published

2022

Language

EN