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Pilot Study of Intraoperative Chemotherapy with Cisplatin and 5-Fluorouracil in Patients with Advanced Squamous Cell Carcinoma of the Head and Neck by Ozlem E. Tulunay; Ileana I. Enamorado; Omer Kucuk; Lance K. Heilbrun; Jose E. Otero; Hakan Korkmaz; Robert Blumberg; John R. Jacobs is a Medicine article available to read on EtoBox.
What is Pilot Study of Intraoperative Chemotherapy with Cisplatin and 5-Fluorouracil in Patients with Advanced Squamous Cell Carcinoma of the Head and Neck about?
## Abstract ## Background. Intraoperative manipulation of the tumor during cancer surgery has long been recognized as a source of metastasis and contamination of the surgical wound during tumor removal. We explored the use of intraoperative chemotherapy to minimize the risk of tumor cell implantation and metastasis during head and neck cancer surgery and conducted a dose escalating intraoperative chemotherapy clinical trial designed to assess the feasibility of this approach and associated toxicities in patients with advanced squamous cell carcinoma of the head and neck. ## Methods. Fourteen patients were treated with 5‐fluorouracil at a dose of 1000 mg/m^2^ administered intravenously over an 8‐hour period during the surgery with simultaneous cisplatin. The cisplatin dose was escalated and toxicity observed. Cisplatin at 75 mg/m^2^ was chosen as the maximum tolerated dose level. ## Results. One patient experienced a grade 3 nephrotoxicity, 1 patient a grade 1 neuropathy, and 5 patients grade 2 nausea (36%). There were no grade 4 toxicities. ## Conclusion. Intraoperative chemotherapy is feasible, and the combination of cisplatin at 75 mg/m^2^ and 5‐fluorouracil at 1000 mg/m^2^ can b
Who reads Pilot Study of Intraoperative Chemotherapy with Cisplatin and 5-Fluorouracil in Patients with Advanced Squamous Cell Carcinoma of the Head and Neck?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Ozlem E. Tulunay; Ileana I. Enamorado; Omer Kucuk; Lance K. Heilbrun; Jose E. Otero; Hakan Korkmaz; Robert Blumberg; John R. Jacobs
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1043-3074)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)