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Degradation of Hyaluronan by Ultrasonication in Comparison to Microwave and Conventional Heating by Evženia Dřímalová; Vladimír Velebný; Vlasta Sasinková; Zdenka Hromádková; Anna Ebringerová is a Materials Science article available to read on EtoBox.
What is Degradation of Hyaluronan by Ultrasonication in Comparison to Microwave and Conventional Heating about?
Hyaluronan (hyaluronic acid, HA) was depolymerised by ultrasonication (US), microwave irradiation (MW) and conventional heating (CH), and the effect of pH and oxidants was investigated. The degradation was followed by viscometry and size exclusion chromatography coupled with low-angle light scattering. The results demonstrated that depolymerisation of HA by US leveled off to a limiting molecular mass, and the degradation was significantly enhanced by acidic and alkaline pH only in the presence of oxidants. In contrast to US, the course of depolymerisation by MW was strongly pH-dependent, and the degradation rate increased with decreasing pH. The expected enhancement of depolymerisation by MW in comparison to CH was marked only at very short heating time at pH !4. The NMR and FTIR spectral analyses indicated that HA in the whole M w -range studied retained almost the backbone of the parent polysaccharide independently on the degradation method used. At harsh degradation conditions (long-term treatments, particularly at acidic pH or alkaline pH and in presence of oxidants) the depolymerisation was accompanied by destruction of both constituent sugar residues and formation of unsatura
Who reads Degradation of Hyaluronan by Ultrasonication in Comparison to Microwave and Conventional Heating?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Evženia Dřímalová; Vladimír Velebný; Vlasta Sasinková; Zdenka Hromádková; Anna Ebringerová
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0144-8617)
- Published
- 2005
- Language
- EN
- Field
- Materials Science (Physical Sciences)