Opening book details…
Can I read Treatment with a short course of LF 15‐0195 and continuous cyclosporin A attenuates acute xenograft rejection in a rat‐to‐mouse cardiac transplantation model on EtoBox?
Treatment with a short course of LF 15‐0195 and continuous cyclosporin A attenuates acute xenograft rejection in a rat‐to‐mouse cardiac transplantation model by Hao Wang; Karoline A. Hosiawa; Bertha Garcia; Jeffrey B. Shum; Patrick Dutartre; David J. Kelvin; Robert Zhong is a Medicine article available to read on EtoBox.
What is Treatment with a short course of LF 15‐0195 and continuous cyclosporin A attenuates acute xenograft rejection in a rat‐to‐mouse cardiac transplantation model about?
Abstract: Searching for a novel immunosuppressive agent to effectively prevent acute vascular rejection (AVR) is essential for success in clinical xenotransplantation. We previously reported that Lewis rat hearts transplanted into BALB/c mice developed typical AVR in 6 days. The present study was undertaken to determine the efficacy of LF 15‐0195, a new immunosuppressive analog of 15‐deoxyspergualin in the prevention of AVR in a rat‐to‐mouse cardiac xenograft model. We transplanted 2‐week old Lewis rat hearts into BALB/c mice. Four groups were included in this study: untreated recipients and cyclosporin A (CsA) treated recipients were controls; LF 15‐0195 treated recipients or LF 15‐0195 combined with CsA treated recipients were experimental groups. Mouse recipients received either LF 15‐0195 2 mg/kg subcutaneously from day‐1 to post‐operative day 14, or CsA 15 mg/kg subcutaneously daily, from day 0 to endpoint rejection, or the two drugs in combination. We observed that high dose CsA did not inhibit AVR and the graft was rejected in 11.3 ± 1.9 days. Graft histology and immunohistology showed typical AVR, characterized by interstitial hemorrhage, intravascular fibrin deposition, th
Who reads Treatment with a short course of LF 15‐0195 and continuous cyclosporin A attenuates acute xenograft rejection in a rat‐to‐mouse cardiac transplantation model?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Hao Wang; Karoline A. Hosiawa; Bertha Garcia; Jeffrey B. Shum; Patrick Dutartre; David J. Kelvin; Robert Zhong
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0908-665X)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)