Can I read Deformable image registration of the treatment planning CT with proton radiographies in perspective of adaptive proton therapy on EtoBox?

Deformable image registration of the treatment planning CT with proton radiographies in perspective of adaptive proton therapy by Prasannakumar Palaniappan; Sebastian Meyer; Florian Kamp; Claus Belka; Marco Riboldi; Katia Parodi; Chiara Gianoli is a Medicine article available to read on EtoBox.

What is Deformable image registration of the treatment planning CT with proton radiographies in perspective of adaptive proton therapy about?

## Abstract The purpose of this work is to investigate the potentiality of using a limited number of in-room proton radiographies to compensate anatomical changes in adaptive proton therapy. The treatment planning CT is adapted to the treatment delivery scenario relying on 2D-3D deformable image registration (DIR). The proton radiographies, expressed in water equivalent thickness (WET) are simulated for both list-mode and integration-mode detector configurations in pencil beam scanning. Geometrical and analytical simulations of an anthropomorphic phantom in the presence of anatomical changes due to breathing are adopted. A Monte Carlo simulation of proton radiographies based on a clinical CT image in the presence of artificial anatomical changes is also considered. The accuracy of the 2D-3D DIR, calculated as root mean square error, strongly depends on the considered anatomical changes and is considered adequate for promising adaptive proton therapy when comparable to the accuracy of conventional 3D-3D DIR. In geometrical simulation, this is achieved with a minimum of eight/nine radiographies (more than 90% accuracy). Negligible improvement (sim1%) is obtained with the use of 180 r

Who reads Deformable image registration of the treatment planning CT with proton radiographies in perspective of adaptive proton therapy?

Author

Prasannakumar Palaniappan; Sebastian Meyer; Florian Kamp; Claus Belka; Marco Riboldi; Katia Parodi; Chiara Gianoli

Publisher

Institute of Physics; IOP Publishing; Institute of Physics Publishing (ISSN 0031-9155)

Published

2020

Language

EN

Field

Medicine (Health Sciences)