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## Acquired drug resistance: case report A 33-year-old man acquired drug resistance to imatinib while being treated for chronic myeloid leukaemia (CML). The man presented to a hospital for his routine checkup of CML treatment. He had been receiving oral imatinib [imatinib mesylate] 1 × 400 mg/day for 2 years. Two years prior, he had presented to the hospital due to nausea and bloating. Clinical examination was significant for anaemia, bilateral conjunctiva and massive splenomegaly. He was diagnosed with CML-CP. He achieved complete haematologic response (CHR) within 3 months after the imatinib initiation. At the current presentation, laboratory investigation showed an increased white blood cell count, platelet count, basophil count and myeloblast count. Quantitative BCR-ABL was 63% IS, which indicated loss of CHR. Bone marrow aspiration showed expansion of granulopoiesis. He lost complete hematological response (CHR), and major molecular response (MMR) was not achieved after 24 months of the treatment. These findings were suggestive of acquired resistance to imatinib.

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Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)