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Synthesis of ^14^C labelled heptacaine and carbisocaine, new local anaesthetics by Tomáš Elbert; Vladimír Marko; Jiří Filip; Luděk Beneš is a Chemistry article available to read on EtoBox.

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## Abstract The published four step synthesis of N‐{2‐(2‐heptyloxyphenyl‐carbamoyloxy)‐ethyl}‐piperidinium chloride (**5**) and N‐{2‐(2‐heptyl‐oxyphenylcarbamoyloxy)‐propyl}‐diethylammonium chloride (**6**), which starts from o‐acetamidophenol and 1‐bromoheptane was scaled down and modified for radioisotope work. After chromatography 1064 MBq (28,7 mCi) of [heptyl‐1‐^14^C]heptacaine **5** and 840 MBq (22, 6 mCi) of [heptyl‐1‐^14^C]carbisocaine **6** were isolated. Radiochemical yields of **5** and **6** on starting 1‐bromo [1‐^14^C] heptane were 30% and 25%, respectively.

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Author

Tomáš Elbert; Vladimír Marko; Jiří Filip; Luděk Beneš

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-2135)

Published

1984

Language

EN

Field

Chemistry (Life Sciences)