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What is EGA Initiation in One-Cell Mouse and Human Embryos about?

Embryonic genome activation (EGA) in mouse and human embryos initiates at the one-cell stage, contrary to previous beliefs that it began at later stages. New evidence from single-cell RNA sequencing indicates that immediate EGA occurs within hours of fertilization, primarily driven by maternal genomic transcription, followed by paternal transcription. This study highlights the significance of EGA in understanding early developmental processes and its implications for epigenetic inheritance and cancer.

Author

fhadila

Language

EN