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Evolution of immunity: Potential immunocompetence of the echinoid axial organ by Maureen K. Larson; Christopher J. Bayne is a Environmental Science article available to read on EtoBox.

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## Abstract Antigen‐specific recognition is a hallmark of vertebrate lymphoid immune responses. Although isolated studies have suggested specific responses in some invertebrate phyla, those claims remain to be independently verified. Echinoderms share the deuterostome lineage with vertebrates and thus represent an important group for examinations into the origins of vertebrate immune competence. Investigations in asteroids suggested axial organ involvement in an antigen‐specific immune response. To independently test this organ's role in echinoid immunity, __Strongylocentrotus purpuratus__ axial organ cells from injected animals were monitored for the production of membrane‐bound and secreted molecules specific for the injected hapten (TNP). Cells of the axial organs were assayed for specific membrane receptors in an immunocytoadherence assay. Urchin axial organ cells did not bind TNP‐sheep red blood cells and, while hemagglutination was observed, it was neither TNP‐inhibitable, nor dependent on previous exposure to TNP. Secretion of antigen‐specific molecules was evaluated by enzyme‐linked immunosorbent assay. Coelomic fluids from several urchins contained molecules that bound TNP

Who reads Evolution of immunity: Potential immunocompetence of the echinoid axial organ?

Author

Maureen K. Larson; Christopher J. Bayne

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-104X)

Published

1994

Language

EN

Field

Environmental Science (Life Sciences)