Opening book details…
Can I read The effect of atovaquone (566C80) on the maturation and viability of Plasmodium falciparum gametocytes in vitro on EtoBox?
The effect of atovaquone (566C80) on the maturation and viability of Plasmodium falciparum gametocytes in vitro by S.L. Fleck; M. Pudney; R.E. Sinden is a Medicine article available to read on EtoBox.
What is The effect of atovaquone (566C80) on the maturation and viability of Plasmodium falciparum gametocytes in vitro about?
Atovaquone (566C80), a hydroxynaphthoquinone, was investigated for activity against Plasmodium J&iparum gametocytes (NF54 strain) in vitro. After 96 h of continuous exposure to the drug at 1.4~ lo-M (a concentration achievable in humans 14 d after administration of a therapeutic dose of 10 mg/kg) reductions of 75%, 54% and 20% in the number, of gametocyte stages 2, 3 and 4, respectively, were achieved. A small increase (14%) in stage 5 gametocytes was seen. At the same concentration, atovaquone showed greater activity against the asexual stages of l? falciparum, reductions of 93%, 96% and 43% in the number of rings, schizonts and trophozoites, respectively, being achieved. These data are consistent with inhibition of maturation of trophozoites. The observed effect on maturation of gametocytes is similarly consistent with blockade of gametocyte recruitment from merozoites produced by the preceding schizogony, or to stasis of intraerythrocytic sexual development before the formation of stage 2 gametocytes.
Who reads The effect of atovaquone (566C80) on the maturation and viability of Plasmodium falciparum gametocytes in vitro?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- S.L. Fleck; M. Pudney; R.E. Sinden
- Publisher
- Elsevier Science; Oxford University Press; Oxford University Press (OUP); ScienceOpen (ISSN 0035-9203)
- Published
- 1996
- Language
- EN
- Field
- Medicine (Health Sciences)