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Porous gelatin–chondroitin–hyaluronate tri-copolymer scaffold containing microspheres loaded with TGF-β1 induces differentiation of mesenchymal stem cells in vivo for enhancing cartilage repair by Hongbin Fan; Yunyu Hu; Ling Qin; Xusheng Li; Hong Wu; Rong Lv is a Engineering article available to read on EtoBox.
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## Abstract The aim of the study was to produce a novel porous gelatin–chondroitin–hyaluronate scaffold in combination with a controlled release of transforming growth factor β1 (TGF‐β1), which induced the differentiation of mesenchymal stem cells (MSCs) __in vivo__ for enhancing cartilage repair. Gelatin microspheres loaded with TGF‐β1 (MS‐TGFβ1) showed a fast release at the initial phase (37.4%), and the ultimate accumulated release was 83.1% by day 18. The autologous MSCs seeded on MS‐TGFβ1/scaffold were implanted to repair full‐thickness cartilage defects in rabbits as __in vivo__ differentiation repair group, while MSCs differentiated __in vitro__ were seeded on scaffold without MS‐TGFβ1 to repair the contra lateral cartilage defects (__n__ = 30). Fifteen additional rabbits without treatment for defects were used as control. Histology observation showed that the __in vivo__ differentiation repair group had better chondrocyte morphology, integration, continuous subchondral bone, and much thicker newly formed cartilage layer when compared to __in vitro__ differentiation repair group 12 and 24 weeks, postoperatively. There was a significant difference in histological grading scor
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- Author
- Hongbin Fan; Yunyu Hu; Ling Qin; Xusheng Li; Hong Wu; Rong Lv
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)
- Published
- 2006
- Language
- EN
- Field
- Engineering (Physical Sciences)