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Diversity of Function and Mechanism in a Family of Organic Anion Transporters by Fei Li; Jacob Eriksen; Janet Finer-Moore; Robert M. Stroud; Robert H. Edwards is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Diversity of Function and Mechanism in a Family of Organic Anion Transporters about?

Originally identified as transporters for inorganic phosphate, solute carrier 17 (SLC17) family proteins subserve diverse physiological roles. The vesicular glutamate transporters (VGLUTs) package the principal excitatory neurotransmitter glutamate into synaptic vesicles (SVs). In contrast, the closely related sialic acid transporter sialin mediates the flux of sialic acid in the opposite direction, from lysosomes to the cytoplasm. The two proteins couple in different ways to the H electrochemical gradient driving force, and high-resolution structures of the Escherichia coli homolog d-galactonate transporter (DgoT) and more recently rat VGLUT2 now begin to suggest the mechanisms involved as well as the basis for substrate specificity.

Who reads Diversity of Function and Mechanism in a Family of Organic Anion Transporters?

Author

Fei Li; Jacob Eriksen; Janet Finer-Moore; Robert M. Stroud; Robert H. Edwards

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)