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Variations in the Expression of Cell‐adhesion Molecules on Liver‐associated Lymphocytes and Peripheral‐blood Lymphocytes in Patients with and Without Liver Metastasis by María García‐Barcina; Ioseba Bidaurrazaga; Véronique Neaud; Paulette Bioulac‐Sage; Charles Balabaud; Fernando Vidal‐Vanaclocha; María Winnock is a Medicine article available to read on EtoBox.
What is Variations in the Expression of Cell‐adhesion Molecules on Liver‐associated Lymphocytes and Peripheral‐blood Lymphocytes in Patients with and Without Liver Metastasis about?
We evaluated the expression of the cell-adhesion molecules (CAM) that might be involved in liver-associated lymphocyte (VU) contacts with other sinusoidal cells and/or be responsible for natural-killer(NK)-and lymphokine-activated killer(LAK) activity in patients with liver metastasis. The LAL population was isolated by sinusoidal high-pressure lavage from partial hepatectomies obtained from patients operated for metastases (n = 13) and benign liver tumors (n = 9). Surface expression of the beta-2-integrin chains (CD I I a, CD I I b, CD I I c and CDI 8), and the beta-I-integrin chains (CD49b, CD49d. CD49f and CDZP), as well as that of members of the immunoglobulin superfamily (CD2, CD54. CD56 and CD58), were analyzed by one-or two-color flow cytometry. Quantitative and qualitative differences were observed in both groups of patients in the expression of CAM between LAL and peripheral blood lymphocytes (PBL). I A L were characterized by an increase in the percentage of CD I I b-, CD49b-. CD49d-, CD54-. CD56-and CD58-positive cells in comparison with PBL. Fluorescence values for CD2, CD I I a, CD 18 and CD56 were higher in LAL than in PBL. Moreover, the population expressing these an
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- Author
- María García‐Barcina; Ioseba Bidaurrazaga; Véronique Neaud; Paulette Bioulac‐Sage; Charles Balabaud; Fernando Vidal‐Vanaclocha; María Winnock
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1995
- Language
- EN
- Field
- Medicine (Health Sciences)