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Global Proteomic Analysis Reveals Lysine Succinylation Contributes to the Pathogenesis of Aortic Aneurysm and Dissection by Hongwei Zhang; Yu Zhang; Haiyue Wang; Peng Yang; Chen Lu; Yu Liu; Zhenyuan Xu; Chenhao Wang; Jia Hu is a Chemistry article available to read on EtoBox.
What is Global Proteomic Analysis Reveals Lysine Succinylation Contributes to the Pathogenesis of Aortic Aneurysm and Dissection about?
Protein lysine succinylation is a recently discovered posttranslational modification. This study examined the role of protein lysine succinylation in the pathogenesis of aortic aneurysm and dissection (AAD). 4D label-free LC-MS/MS analysis was used to perform the global profiles of succinylation in aortas obtained from 5 heart transplant donors, 5 patients with thoracic aortic aneurysm (TAA), and 5 patients with thoracic aortic dissection (TAD). In comparison to normal controls, we detected 1138 succinylated sites from 314 proteins in TAA, and 1499 sites from 381 proteins in TAD. Among these, 120 differentially succinylated sites from 76 proteins overlapped between TAA and TAD (|log2FC| > 0.585, p < 0.05). These differentially modified proteins were mainly localized in the mitochondria and cytoplasm, and were primarily involved in diverse energy metabolic processes, including carbon metabolism, amino acid catabolism, and β-oxidation of fatty acids. By establishing an in vitro model of lysine succinylation in vascular smooth muscle cells, we observed changes in the activities of three key metabolic enzymes (PKM, LDHA, and SDHA). These findings suggest that succinylation potentially
Who reads Global Proteomic Analysis Reveals Lysine Succinylation Contributes to the Pathogenesis of Aortic Aneurysm and Dissection?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Hongwei Zhang; Yu Zhang; Haiyue Wang; Peng Yang; Chen Lu; Yu Liu; Zhenyuan Xu; Chenhao Wang; Jia Hu
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Chemistry (Physical Sciences)