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Metabolic stroke or stroke-like lesion: Peculiarities of a phenomenon by Josef Finsterer; Rahim Aliyev is a Medicine article available to read on EtoBox.

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## Objectives: One of the most frequent cerebral lesions in mitochondrial disorders(mids) on imaging is the stroke-like lesion(sll) clinically manifesting as stroke-like episode (sle, metabolic stroke). this review aims at discussing recent advances concerning the presentation, diagnosis, and treatment of slls. ## Methods: Systematic literature review using appropriate search terms. ## Results: Slls are the hallmark of melas but occasionally occur in other mids. slls are best identified on multimodal, cerebral mri. slls may present as uni-/multilocular, symmetric/asymmetric, cortical/subcortical, supra-/infratentorial condition, initially resembling a cytotoxic edema and later a vasogenic edema, or a variable mix between them. slls run through an acute and a chronic stage. the acute stage is characterised by a progressively expanding lesion over days, weeks, or months, showing up as increasing hyperintensity on t2/flair, dwi, and pwi and by hyperperfusion, that does not conform to a vascular territory. adc maps are initially hypointens to become hyperintens during the course. more rarely, a variable mixture of hyper- and hypointensities may be found. the chronic stage is characteri

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Author

Josef Finsterer; Rahim Aliyev

Publisher

Elsevier BV

Published

2020

Language

EN

Field

Medicine (Health Sciences)