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New 29-nor-cycloartanes with a 3,4-seco- and a novel 2,3-seco-structure from the leaves of Sinocalycanthus chinensis by Yoshiki Kashiwada; Kazuya Nishimura; Shin-ichiro Kurimoto; Yoshihisa Takaishi is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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seco-29-nor-Cycloartane MDR a b s t r a c t Eight new triterpenoids, including sinocalycanchinensins A-E (1-5) with a 3,4-seco-29-nor-cycloartane skeleton, sinocalycanchinensin F (6) possessing a novel 2,3-seco-29-nor-cycloartane skeleton, and 29nor-cycloartanes, sinocalycanchinensins G and H (7 and 8), have been isolated from the leaves of Sinocalycanthus chinensis. Their structures were elucidated on the basis of spectroscopic examinations. The cytotoxicities of the isolated new triterpenes against a panel of human cancer cell lines, including multi-drug resistant (MDR) cancer cell lines, were also evaluated. Compound 5 demonstrated enhanced cytotoxicity against MDR KB cells in the presence of colchicine, although all the compounds showed moderate or no cytotoxicities.

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Author

Yoshiki Kashiwada; Kazuya Nishimura; Shin-ichiro Kurimoto; Yoshihisa Takaishi

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)