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Exploring the Role of Chirality in Nucleic Acid Recognition by Daniele D'Alonzo; Annalisa Guaragna; Giovanni Palumbo is a Agricultural and Biological Sciences article available to read on EtoBox.

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## Abstract The study of the base‐pairing properties of nucleic acids with sugar moieties in the backbone belonging to the L‐series (__β__‐L‐DNA, __β__‐L‐RNA, and their analogs) are reviewed. The major structural factors underlying the formation of stable heterochiral complexes obtained by incorporation of modified nucleotides into natural duplexes, or by hybridization between homochiral strands of opposite sense of chirality are highlighted. In addition, the perspective use of L‐nucleic acids as candidates for various therapeutic applications, or as tools for both synthetic biology and etiology‐oriented investigations on the structure and stereochemistry of natural nucleic acids is discussed.

Who reads Exploring the Role of Chirality in Nucleic Acid Recognition?

Author

Daniele D'Alonzo; Annalisa Guaragna; Giovanni Palumbo

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 1612-1872)

Published

2011

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)