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Can I read Prostaglandin Release by Spinal Cord Injury Mediates Production of Hydroxyl Radical, Malondialdehyde and Cell Death: a Site of the Neuroprotective Action of Methylprednisolone on EtoBox?
Prostaglandin Release by Spinal Cord Injury Mediates Production of Hydroxyl Radical, Malondialdehyde and Cell Death: a Site of the Neuroprotective Action of Methylprednisolone by Danxia Liu; Liping Li; Lezel Augustus is a Neuroscience article available to read on EtoBox.
What is Prostaglandin Release by Spinal Cord Injury Mediates Production of Hydroxyl Radical, Malondialdehyde and Cell Death: a Site of the Neuroprotective Action of Methylprednisolone about?
The present study explores __in vivo__ whether and how prostaglandin F~2α~ (PGF~2α~), a membrane phospholipid hydrolysis product, causes neuronal death. The concentration of PGF~2α~ measured by microdialysis sampling increased threefold immediately following impact injury to the rat spinal cord. Administration of PGF~2α~ into the cord through a dialysis fiber caused significant cell loss, increased extracellular levels of hydroxyl radicals and malondialdehyde – an end product of membrane lipid peroxidation – to 3.3 and 2.3 times basal levels, respectively. This suggests that PGF~2α~‐induced cell death is partly due to hydroxyl radical‐triggered peroxidation. Generating hydroxyl radical by administering Fenton's reagents into the cord through the fibers significantly increased malondialdehyde production – the first direct __in vivo__ evidence that hydroxyl radical triggers membrane lipid peroxidation. Methylprednisolone significantly reduced the release of PGF~2α~ upon spinal cord injury and blocked PGF~2α~‐induced hydroxyl radical and malondialdehyde production, but did not significantly reduce Fenton's reagent‐induced malondialdehyde production, despite the production of more malo
Who reads Prostaglandin Release by Spinal Cord Injury Mediates Production of Hydroxyl Radical, Malondialdehyde and Cell Death: a Site of the Neuroprotective Action of Methylprednisolone?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Danxia Liu; Liping Li; Lezel Augustus
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)
- Published
- 2001
- Language
- EN
- Field
- Neuroscience (Life Sciences)