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Can I read Ganglioside GM2 on the K562 cell line is recognized as a target structure by human natural killer cells on EtoBox?
Ganglioside GM2 on the K562 cell line is recognized as a target structure by human natural killer cells by Iwao Ando; Dave S. B. Hoon; Yasuo Suzuki; Romaine E. Saxton; Sidney H. Golub; Reiko F. Irie is a Medicine article available to read on EtoBox.
What is Ganglioside GM2 on the K562 cell line is recognized as a target structure by human natural killer cells about?
Although human N K cells lyse a wide spectrum of target cells, the precise target structure recognized by N K cells has not yet been elucidated. In order to define a possible relationship between gangliosides on human target cells and susceptibility to N K lysis. 14 human leukemia and lymphoma cell lines were studied. A significant correlation was observed between the quantity of ganglioside GM2 on the target cells and sensitivity to N K lysis. In a single-cell binding assay purified GM2 specifically inhibited human N K cell binding to K562 target cells while other gangliosides did not inhibit binding. The competitive inhibition of N K cells by GM2 was restricted to the source of tissue from which GM2 was isolated. These results indicate that GM2 is a strong candidate as a target recognition structure for human N K cells.
Who reads Ganglioside GM2 on the K562 cell line is recognized as a target structure by human natural killer cells?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Iwao Ando; Dave S. B. Hoon; Yasuo Suzuki; Romaine E. Saxton; Sidney H. Golub; Reiko F. Irie
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1987
- Language
- EN
- Field
- Medicine (Health Sciences)