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Power Spectral Changes of Quantitative EEG in the Subjective Cognitive Decline: Comparison of Community Normal Control Groups by Ho Tae Jeong; Young Chul Youn; Hyun-Ho Sung; Sang Yun Kim is a Medicine article available to read on EtoBox.

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## Purpose The purpose of this study is to compare and analyze the power spectral changes between subjective cognitive decline (SCD) subjects and normal controls (NC) while checking the preclinical stage of AD in the SCD subjects and to use the derived data for biomarker research that can diagnose early-stage AD in the future. ## Methods We recruited 23 SCD patients and 23 normal control subjects and QEEG analysis including power spectral density (PSD) and source-level analysis were performed. An automated preprocessing procedure and statistical analysis were performed by iSync Brain^®^ (iMediSync Inc., Republic of Korea) (https://isyncbrain.com/) using the international standard 10–20 system (19 electrodes). ## Results Absolute PSD, there was no statistically significant difference in all of the EEG power measurements of the 19 channels. In the relative PSD analysis, the average delta band power of the SCD group was significantly higher in Fp2, F4, and F8 than NC. Alpha1 band power of the O1 channel was 22.56±16.05 for the SCD group and 33.19±19.05 for the NC (p-value <0.05). Source-level analysis did not show a statistically significant difference. ## Conclusion SCD subjects show

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Author

Ho Tae Jeong; Young Chul Youn; Hyun-Ho Sung; Sang Yun Kim

Publisher

Informa UK Limited

Published

2021

Language

EN

Field

Medicine (Health Sciences)