Can I read Synthesis of 3-(4-carbamoylpyridiniomethyl)-7B-(2-sulfophenyl-acetamido)-ceph-3-em-carboxylate monosodium salt labelled at [14C]carbamoyl and [1-14C]acetamido groups on EtoBox?

Synthesis of 3-(4-carbamoylpyridiniomethyl)-7B-(2-sulfophenyl-acetamido)-ceph-3-em-carboxylate monosodium salt labelled at [14C]carbamoyl and [1-14C]acetamido groups by Nobuyoshi Hayashi; Tadashi Toga; Norio Tada; Toshiyuki Azuma is a Chemistry article available to read on EtoBox.

What is Synthesis of 3-(4-carbamoylpyridiniomethyl)-7B-(2-sulfophenyl-acetamido)-ceph-3-em-carboxylate monosodium salt labelled at [14C]carbamoyl and [1-14C]acetamido groups about?

## OC-Sulfobenzylpenicillin as a new semi-synthetic penicillin having a broad antibiotic spectrum against Gram-positive and negative bacteria was first prepared in these laboratories and has already been supplied to clinical use. Moreover, many semisynthetic penicillins and cephalosporins have been synthesized in order to seek for high effective antipseudomonal medicament without toxicity. Among these synthetic and biological studies, 3-(4-carbamoylpyridiniomethyl)-78-(D-2-sulfophenylacet~ido)-ceph-3-em-4-carboxylate monosodium salt (SCE-129) appeared to be one of the most potent antipseudomonal compounds ever known in the)-lactam antibiotics. (2) [ C]carbamoylpyridiniomethyl)-7~-(D-2-sulfophenylacet~ido)-ceph-3-em-4-carboxylate monosodium salt (VI) and 3-(4-carbamoylpyridiniomethyl) -7b-(DL-2-sulfophenyl-[ 1-14C] acetamido) -ceph-3-em-4-carboxylate monosodium salt (XII). By the well known procedure, [~arboxyl-~~C] isonicotinic acid (111) was obtained from the reaction of 14C02 with 4-pyridyl lithium which was prepared from 4-bromopyridine, and treated with S0Cl2, followed by ammonia to give [~arbonyl-~'C] isonicotinamide (V) . This paper deals with the syntheses of 3-(4-14 (3) Con

Who reads Synthesis of 3-(4-carbamoylpyridiniomethyl)-7B-(2-sulfophenyl-acetamido)-ceph-3-em-carboxylate monosodium salt labelled at [14C]carbamoyl and [1-14C]acetamido groups?

Author

Nobuyoshi Hayashi; Tadashi Toga; Norio Tada; Toshiyuki Azuma

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-2135)

Published

1978

Language

EN

Field

Chemistry (Life Sciences)