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Troglitazone Inhibits Cell Migration, Adhesion, and Spreading by Modulating Cytoskeletal Rearrangement in Human Breast Cancer Cells by Pei‐Shan Wang; Fu‐Sheng Chou; Leonardo Porchia; Motoyasu Saji; Joseph J. Pinzone is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Troglitazone Inhibits Cell Migration, Adhesion, and Spreading by Modulating Cytoskeletal Rearrangement in Human Breast Cancer Cells about?
## Abstract Metastatic tumors are the primary cause of death in patients with breast cancer. Recent data indicate that the peroxisome proliferator‐activated receptor γ (PPARγ) ligands, thiazolidinediones (TZDs), possess anti‐invasive activities on human breast cancer cells. However, the effects of TZDs on other metastatic properties of breast cancer cells such as adhesion, spreading, and migration are not well established. In this study, we show that troglitazone (TG), a member of the TZD family, inhibits lamellipodia formation or membrane ruffling as well as actin polymerization at these structures in MDA‐MB‐231 and T47D breast cancer cells. In addition, TG reduces migration, adhesion, and spreading on fibronectin (FN)‐coated plates. These phenomena were associated with the dramatic decrease of Tyr397 and Tyr576 phosphorylation of focal adhesion kinase (FAK) and the detergent‐insoluble Rac1. We also found that TG upregulates Tyr416 phosphorylation of Src, but downregulates the Src–FAK complex. Moreover, we use a PPARγ‐inactive derivative of TG (STG28) and a PPARγ antagonist (GW9662) to eliminate PPARγ‐mediated effects. We found that treatment with STG28 or GW9662 plus TG showed si
Who reads Troglitazone Inhibits Cell Migration, Adhesion, and Spreading by Modulating Cytoskeletal Rearrangement in Human Breast Cancer Cells?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Pei‐Shan Wang; Fu‐Sheng Chou; Leonardo Porchia; Motoyasu Saji; Joseph J. Pinzone
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-1987)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)