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Factors Influencing Intestinal Microparticle Uptake in Vivo by M. Doyle-McCullough; S.H. Smyth; S.M. Moyes; K.E. Carr is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

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The aim of this study is to compare microparticle uptake in animals of different ages, gender and species and at different time points. The 2 m latex/in vivo in situ model uses the observation of animal responses or post-mortem changes and also particle identification by fluorescence microscopy in nine sequential intestinal segments and secondary sites. The wide size range of animals studied requires particle numbers in tissue compartments to be related to intestinal tissue section area through a circumference measurement. Area under the curve (AUC) data for particles in intestinal tissue are plotted against measurements of intestinal length, allowing comparisons to be made across different ages and species and between males and females. The percentage uptake of administered dose and particle numbers in macerated tissue are also reported. Some parameters, in particular species, do not appear to affect the extent of microparticle uptake, which ranges from 0.12 to 0.32% of the administered dose. Particle uptake does, however, vary with age, being significantly greater in young adult males (7 weeks) than in younger (3 weeks) and older (17 and 52 weeks) age groups. It is concluded that

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Author

M. Doyle-McCullough; S.H. Smyth; S.M. Moyes; K.E. Carr

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

2007

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)