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Can I read SATR-1 hypomethylation is a common and early event in breast cancer on EtoBox?
SATR-1 hypomethylation is a common and early event in breast cancer by Fabrício F. Costa; Valeria A. Paixão; Felicia P. Cavalher; Karina B. Ribeiro; Isabela W. Cunha; José Augusto Rinck; Michael O'Hare; Alan Mackay; Fernando A. Soares; Ricardo R. Brentani; Anamaria A. Camargo is a Medicine article available to read on EtoBox.
What is SATR-1 hypomethylation is a common and early event in breast cancer about?
Genome stability and normal gene expression are maintained by a fixed and predetermined DNA methylation pattern, which becomes abnormal in malignant cells. Hypomethylation of satellite DNA sequences is frequently found in tumors and has been associated with an increased frequency of DNA rearrangements and chromosome instability. In this work, we used methylation-sensitive arbitrarily primed polymerase chain reaction (MSAP-PCR) to identify differentially methylated DNA fragments in normal and tumor breast samples. We identified a novel differentially methylated fragment located on chromosome 5 with high similarity to a SATR-1 satellite sequence. This fragment was found to be hypomethylated in 63% of breast tumor cell lines and in 86% of breast tumors relative to normal breast tissue. We found that normal tissue adjacent to breast tumors displayed a variable decrease in methylation and that the decrease observed for most of these adjacent samples was higher than observed for normal breast tissue derived from reduction mammoplasty. The methylation decrease was, however, significantly higher in tumor samples than in adjacent tissue (χ2 = 154, 1 df, P < 10−4), suggesting that SATR-1 hyp
Who reads SATR-1 hypomethylation is a common and early event in breast cancer?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Fabrício F. Costa; Valeria A. Paixão; Felicia P. Cavalher; Karina B. Ribeiro; Isabela W. Cunha; José Augusto Rinck; Michael O'Hare; Alan Mackay; Fernando A. Soares; Ricardo R. Brentani; Anamaria A. Camargo
- Publisher
- Elsevier BV
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)