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Can I read Diphenhydramine as an Adjunct to Sedation for Colonoscopy: a Double-blind Randomized, Placebo-controlled Study on EtoBox?
Diphenhydramine as an Adjunct to Sedation for Colonoscopy: a Double-blind Randomized, Placebo-controlled Study by Raymond H. Tu; Pam Grewall; Joseph W. Leung; Arun G. Suryaprasad; Paul I. Sheykhzadeh; Caitlin Doan; Juan Carlos Garcia; Nan Zhang; Thomas Prindiville; Surinder Mann; Walter Trudeau is a Medicine article available to read on EtoBox.
What is Diphenhydramine as an Adjunct to Sedation for Colonoscopy: a Double-blind Randomized, Placebo-controlled Study about?
## Background: Intravenous benzodiazepines in combination with opiates are used to achieve moderate sedation for colonoscopy. although effective, these agents have potential adverse effects, such as respiratory depression and hypotension. diphenhydramine hydrochloride possesses central nervous system depressant effects that theoretically could provide a synergistic effect for sedating patients. ## Objective: The objective was to assess the efficacy of adding diphenhydramine hydrochloride as an adjunct to improve sedation and to reduce the amount of standard sedatives used during colonoscopy. ## Design: We conducted a prospective, randomized, double-blind, placebo-controlled study. ## Setting: The study was conducted in a university hospital with an active gi fellowship training program. ## Patients: The study group comprised 270 patients undergoing screening/diagnostic/therapeutic colonoscopy were enrolled. ## Interventions: Patients were randomized to receive either 50 mg of diphenhydramine or placebo, given intravenously 3 minutes before starting conscious sedation with intravenous midazolam and meperidine. ## Main outcome measurements: The main outcome measure was anesthetic eff
Who reads Diphenhydramine as an Adjunct to Sedation for Colonoscopy: a Double-blind Randomized, Placebo-controlled Study?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Raymond H. Tu; Pam Grewall; Joseph W. Leung; Arun G. Suryaprasad; Paul I. Sheykhzadeh; Caitlin Doan; Juan Carlos Garcia; Nan Zhang; Thomas Prindiville; Surinder Mann; Walter Trudeau
- Publisher
- Elsevier BV
- Published
- 2006
- Language
- EN
- Field
- Medicine (Health Sciences)