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Interactions of Human Immunodeficiency Virus-1 Proteins with Neurons: Possible Role in the Development of Human Immunodeficiency Virus-1-associated Dementia by M. Van De Bovenkamp; H. S. L. M. Nottet; C. F. Pereira is a Medicine article available to read on EtoBox.

What is Interactions of Human Immunodeficiency Virus-1 Proteins with Neurons: Possible Role in the Development of Human Immunodeficiency Virus-1-associated Dementia about?

## Abstract Human immunodeficiency virus‐1 (HIV‐1)‐associated dementia is a severe neurological complication of HIV‐1 infection that affects 15–20% of the patients in the late stages of acquired immunodeficiency syndrome. HIV‐1‐associated dementia is most probably a consequence of HIV‐1 infection of the brain rather than of an opportunistic pathogen. The exact mechanism by which the virus causes this disorder, however, is not completely understood. A number of HIV‐1 proteins have been shown to be released from HIV‐1‐infected cells and/or to be present in the extracellular milieu in the HIV‐1‐infected brain. Moreover, these proteins have been shown to posses neurotoxic and/or neuromodulatory features __in vitro__. This review describes the possible direct interactions of the HIV‐1 proteins gp120, gp41, vpr, tat, rev, vpu and nef with neurons, which might play a role in the development of HIV‐1‐associated dementia __in vivo__.

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Author

M. Van De Bovenkamp; H. S. L. M. Nottet; C. F. Pereira

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0014-2972)

Published

2002

Language

EN

Field

Medicine (Health Sciences)