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Can I read Decreased Expression of Thrombomodulin Is Correlated with Tumor Cell Invasiveness and Poor Prognosis in Nonsmall Cell Lung Cancer on EtoBox?
Decreased Expression of Thrombomodulin Is Correlated with Tumor Cell Invasiveness and Poor Prognosis in Nonsmall Cell Lung Cancer by Po-Len Liu; Jong-Rung Tsai; Chien-Chih Chiu; Jhi-Jhu Hwang; Shah-Hwa Chou; Chih-Kuang Wang; Shu-Jing Wu; Yuh-Lien Chen; Wen-Chi Chen; Yung-Hsiang Chen; Inn-Wen Chong is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Decreased Expression of Thrombomodulin Is Correlated with Tumor Cell Invasiveness and Poor Prognosis in Nonsmall Cell Lung Cancer about?
## Abstract Thrombomodulin (TM) plays a role in coagulation, inflammation, and cell adhesion. Reduction of TM expression plays an important role in the tumor metastatic process; however, insufficient information is available regarding the expression of TM in nonsmall cell lung cancer (NSCLC). Sixty NSCLC patients who underwent surgery were reviewed for TM expression and multiple variables were assessed by univariate and multivariate analyses. The expression level of TM and its metastatic ability were examined in vitro using the human NSCLC A549 cell line. TM expression in NSCLC was significantly correlated with survival; the 5‐yr survival rates of patients with high and low TM expression were 23% and 18% (__P__ < 0.01), respectively. Distribution of TM was detected predominantly in the normal lung tissue compared with lung cancer tissue. Western blot analysis showed, on average, decreased expression levels of TM protein in the lung cancer tissues of patients with NSCLC. An in vitro study also showed that overexpression of TM can inhibit the invasiveness and migration ability of the A549 cell line, whereas silencing of TM significantly enhanced these processes. This inhibition of ce
Who reads Decreased Expression of Thrombomodulin Is Correlated with Tumor Cell Invasiveness and Poor Prognosis in Nonsmall Cell Lung Cancer?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Po-Len Liu; Jong-Rung Tsai; Chien-Chih Chiu; Jhi-Jhu Hwang; Shah-Hwa Chou; Chih-Kuang Wang; Shu-Jing Wu; Yuh-Lien Chen; Wen-Chi Chen; Yung-Hsiang Chen; Inn-Wen Chong
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-1987)
- Published
- 2010
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)