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The study investigates the clinicopathological parameters associated with microsatellite instability (MSI) in endometrial cancer (EC) with MLH1 gene methylation. It includes 89 women treated for EC, finding MSI in 22% of endometrioid adenocarcinomas, with significant associations between MLH1 hypermethylation and younger patient age. The research suggests that MSI phenotype with MLH1 hypermethylation may serve as an unfavorable prognostic marker in sporadic ECs.

Author

Morgana Paiva

Language

EN