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The association of paraoxonase 1 activities, serum mRNA expression and polymorphisms with in-stent coronary restenosis; a case-control study by Sara Saffar Soflaei; Mojtaba Baktashian; Maryam Saberi-Karimian; Habibollah Esmaily; Mohsen Moohebati; Mahmoud Ebrahimi; Aida Gholoobi; Seyed Mohammad Hashemi; Hamideh Ghazizadeh; Gordon A. Ferns; Mansoor Salehi; Alireza Pasdar; Majid Ghayour-Mobarhan is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is The association of paraoxonase 1 activities, serum mRNA expression and polymorphisms with in-stent coronary restenosis; a case-control study about?
Background PON1 polymorphisms and enzyme activity have been reported to be associated with cardiovascular disease (CVD). The aim of current study was to assess the association of these PON1 SNPs and serum enzyme activity and with restenosis following coronary artery stenting. Methods A total of 306 unrelated Iranian patients with history of coronary stent implantation who underwent elective re-angiography were enrolled in the current study. Three single nucleotide polymorphisms (SNPs) of PON1 gene were genotyped. We used a double ARMS PCR method for genotyping at the Q192R and L55M loci, and PCR-RFLP method for C-108 T. Serum mRNA expression of PON1 was determined using SYBER green method and Roche LightCycler. Results There were 104 patients considered as in-stent restenosis (ISR) (mean age: 60.55 ± 8.60 years), and 202 individuals as non ISR (NISR) (mean age: 61.94 ± 9.18 years). There were no significant difference between paraoxonase and arylestrase actvities of paraoxonase 1 enzyme. Furthermore, there were no significant differences in the distribution of genotypes of PON1 polymorphism with ISR compared to the control group. The AAC haplotype was the most frequent haplotype in
Who reads The association of paraoxonase 1 activities, serum mRNA expression and polymorphisms with in-stent coronary restenosis; a case-control study?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Sara Saffar Soflaei; Mojtaba Baktashian; Maryam Saberi-Karimian; Habibollah Esmaily; Mohsen Moohebati; Mahmoud Ebrahimi; Aida Gholoobi; Seyed Mohammad Hashemi; Hamideh Ghazizadeh; Gordon A. Ferns; Mansoor Salehi; Alireza Pasdar; Majid Ghayour-Mobarhan
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)