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Tolerability of levetiracetam in elderly patients with CNS disorders by Joyce A Cramer; Ilo E Leppik; Katrien De Rue; Pascal Edrich; Günter Krämer is a Medicine article available to read on EtoBox.

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The purpose of this analysis was to compare treatment-emergent adverse events (TEAE) related to use of levetiracetam (LEV) reported by young and elderly patients with anxiety and cognitive disorders, and young epilepsy patients. The LEV database includes reports of TEAE from trials of patients with diagnoses of a cognitive disorder (N = 719), an anxiety disorder (N = 1510), or localization-related epilepsy (N = 1023) who participated in clinical trials lasting up to 16 weeks. Patients were grouped as young ( 3% higher for LEV than for placebo-treated patients) in headache (5.2% elderly, -0.9% young, P = 0.041), and tremor (5.2 and -0.5%, respectively, P = 0.022) and between young anxiety patients and young epilepsy patients for somnolence (-0.7 and 5.4%, respectively, P = 0.036). For the other TEAEs there was no evidence for consistent differences between young and elderly patients and between patients with different CNS disorders. Overall, LEV was well tolerated by all patient groups. The favorable adverse event profile suggests that LEV might be suitable for use by elderly patients.

Who reads Tolerability of levetiracetam in elderly patients with CNS disorders?

Author

Joyce A Cramer; Ilo E Leppik; Katrien De Rue; Pascal Edrich; Günter Krämer

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0920-1211)

Published

2003

Language

EN

Field

Medicine (Health Sciences)