Can I read Advanced acquired immune deficiency syndrome-related Kaposi's sarcoma. Results of pilot studies using combination chemotherapy on EtoBox?

Advanced acquired immune deficiency syndrome-related Kaposi's sarcoma. Results of pilot studies using combination chemotherapy by Parkash S. Gill; Mark U. Rarick; Byron Espina; Carmen Loureiro; Marjorie Bernstein-Singer; Bisher Akil; Alexandra M. Levine is a Medicine article available to read on EtoBox.

What is Advanced acquired immune deficiency syndrome-related Kaposi's sarcoma. Results of pilot studies using combination chemotherapy about?

Pilot studies were conducted to evaluate the toxicity and efficacy of two relatively marrow-sparing chemotherapy regimens in the treatment of advanced or progressive epidemic Kaposi's sarcoma. Chemotherapy regimens consisted of bleomycin (10 mg/m2), vincristine (1.4 mg/m2, 2 mg maximum) and Adriamycin (doxorubicin) at either 10 mg/m2 (Group I) or 20 mg/m2 (Group 11). The therapy was given intravenously, every 2 weeks, until intolerable toxicity or maximum antitumor response. Thirty-three patients were treated. Although the patient populations were similar regarding pretreatment prognostic factors, the patients were not assigned randomly to these two treatment regimens. Major responses (complete or partial remission) were attained in 79% of the cases. The treatment-related toxicities consisted of mild to moderate nausea, hair loss, and peripheral sensory neuropathy. Bone marrow suppression consisted primarily of neutropenia (< 1000/mm3) which occurred in a third of the patients. Variables significantly associated with shorter survival included hemoglobin (< 10 g/dl), low Karnofsky performance status (< 70%), and weight loss. Opportunistic infections occurred in the majority of cases

Who reads Advanced acquired immune deficiency syndrome-related Kaposi's sarcoma. Results of pilot studies using combination chemotherapy?

Author

Parkash S. Gill; Mark U. Rarick; Byron Espina; Carmen Loureiro; Marjorie Bernstein-Singer; Bisher Akil; Alexandra M. Levine

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

1990

Language

EN

Field

Medicine (Health Sciences)