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What is Hydroxyquinolines As Cell-Active Histone Demethylase about?

This study identifies 8-hydroxyquinolines as effective inhibitors of the JMJD2 family of histone demethylases through high-throughput screening of a 236,000 compound library. The inhibitors were shown to bind to the active site iron and modulate demethylation at the H3K9 locus in cell-based assays. These findings provide a foundation for developing selective agents to explore epigenetic regulation and potential therapeutic applications.

Author

Ranjan Chatterjee

Language

EN