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Laboratory markers associated with COVID‐19 progression in patients with or without comorbidity: A retrospective study by Zaishu Chen; Furong Zhang; Weihua Hu; Qijian Chen; Chang Li; Longlong Wu; Zhuheng Zhang; Bin Li; Qifa Ye; Jin Mei; Jiang Yue is a Medicine article available to read on EtoBox.
What is Laboratory markers associated with COVID‐19 progression in patients with or without comorbidity: A retrospective study about?
## Objectives: To investigate laboratory markers for covid-19 progression in patients with different medical conditions. ## Methods: We performed a multicenter retrospective study of 836 cases in hubei. to avoid the collinearity among the indicators, principal component analysis (pca) followed by partial least squares discriminant analysis (pls-da) was performed to obtain an overview of laboratory assessments. multivariable logistic regression analysis and multivariable cox proportional hazards regression analysis were respectively used to explore risk factors associated with disease severity and mortality. survival analysis was performed in patients with the most common comorbidities. ## Results: Lactate dehydrogenase (ldh) and prealbumin were associated with disease severity in patients with or without comorbidities, indicated by both pca/pls-da and multivariable logistic regression analysis. the mortality risk was associated with age, ldh, c-reactive protein (crp), d-dimer, and lymphopenia in patients with comorbidities. crp was a risk factor associated with short-term mortality in patients with hypertension, but not liver diseases; additionally, d-dimer was a risk factor for de
Who reads Laboratory markers associated with COVID‐19 progression in patients with or without comorbidity: A retrospective study?
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- Author
- Zaishu Chen; Furong Zhang; Weihua Hu; Qijian Chen; Chang Li; Longlong Wu; Zhuheng Zhang; Bin Li; Qifa Ye; Jin Mei; Jiang Yue
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-8013)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)