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Can I read Novel insights to study the potential of the somatostatin system in NETs and NECs on EtoBox?
Novel insights to study the potential of the somatostatin system in NETs and NECs by Federica Mangili; M. Moreno-Montilla; P. Salamanca-Jiménez; V. García-Vioque; R. Blázquez-Encinas; E. Alors-Pérez; G. Mantovani; E. Peverelli; J. Schrader; A. Ibáñez-Costa; J. Castaño is a Medicine article available to read on EtoBox.
What is Novel insights to study the potential of the somatostatin system in NETs and NECs about?
Results: The levels of BAs were significantly higher in the PDACþOJ group compared to the healthy control. Treating PDAC cells with different BAs or with human serum obtained from PDACþOJ patients enhanced the rate of proliferation, migration, adhesion, colony forming, and the expression of MUC4. In PDACþOJ patients, MUC4 expression was higher and the 4-year survival rate was lower compare to PDAC patients. Silencing of MUC4 decreased BAs-induced carcinogenic processes in PDAC cells. Our results show that BAs promote carcinogenic process in PDAC cells, in which the increased expression of MUC4 plays an important role.Conclusions: These results indicate that in PC patients, where the disease is associated with OJ, the early treatment of biliary obstruction improves life expectancy.
Who reads Novel insights to study the potential of the somatostatin system in NETs and NECs?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Federica Mangili; M. Moreno-Montilla; P. Salamanca-Jiménez; V. García-Vioque; R. Blázquez-Encinas; E. Alors-Pérez; G. Mantovani; E. Peverelli; J. Schrader; A. Ibáñez-Costa; J. Castaño
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)