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Can I read RNA methylation in hematological malignancies and its interactions with other epigenetic modifications on EtoBox?
RNA methylation in hematological malignancies and its interactions with other epigenetic modifications by Lan Yao; Hua Yin; Mei Hong; Yajun Wang; Tingting Yu; Yao Teng; Tingting Li; Qiuling Wu is a Medicine article available to read on EtoBox.
What is RNA methylation in hematological malignancies and its interactions with other epigenetic modifications about?
Hematological malignancies are a class of malignant neoplasms attributed to abnormal differentiation of hematopoietic stem cells (HSCs). The systemic involvement, poor prognosis, chemotherapy resistance, and recurrence common in hematological malignancies urge researchers to look for novel treatment targets and mechanisms. In recent years, epigenetic abnormalities have been shown to play a vital role in tumorigenesis and progression in hematological malignancies. In addition to DNA methylation and histone modifications, which are most studied, RNA methylation has become increasingly significant. In this review, we elaborate recent advances in the understanding of RNA modification in the pathogenesis, diagnosis and molecular targeted therapies of hematological malignancies and discuss its intricate interactions with other epigenetic modifications, including DNA methylation, histone modifications and noncoding RNAs.
Who reads RNA methylation in hematological malignancies and its interactions with other epigenetic modifications?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Lan Yao; Hua Yin; Mei Hong; Yajun Wang; Tingting Yu; Yao Teng; Tingting Li; Qiuling Wu
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)