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What is Bendamustine: Mechanism and Effects about?

Bendamustine is an alkylating chemotherapy drug administered intravenously. It works by forming crosslinks in DNA, preferentially at guanine bases, which can lead to DNA damage and cell cycle arrest or apoptosis. Resistance can develop through increased DNA repair, drug efflux, or glutathione-mediated detoxification. It has a short half-life of 30 minutes and is extensively metabolized in the liver. Adverse effects include reversible myelosuppression and gastrointestinal issues. It is used to treat chronic

Author

BigBoosting

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EN