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This research article describes a study investigating the role of the transcription factor ZBP-89 in hematopoietic development in zebrafish and mouse embryonic stem cells. The key findings are: 1) Knockdown of ZBP-89 in zebrafish embryos results in a "bloodless" phenotype due to disruption of both primitive and definitive hematopoiesis, while leaving blood vessel formation intact. 2) Forced expression of ZBP-89 induces expansion of hematopoietic progenitors in zebrafish and mouse embryonic stem cell cult

Author

Neelra Jeanlo

Language

EN