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Controlled Drug Release from Multilayered Phospholipid Polymer Hydrogel on Titanium Alloy Surface by Jiyeon Choi; Tomohiro Konno; Madoka Takai; Kazuhiko Ishihara is a Engineering article available to read on EtoBox.

What is Controlled Drug Release from Multilayered Phospholipid Polymer Hydrogel on Titanium Alloy Surface about?

Here we describe the functionalization of a multilayered hydrogel layer on a Ti alloy with an antineoplastic agent, paclitaxel (PTX). The multilayered hydrogel was synthesized via layer-by-layer self-assembly (LbL) using selective intermolecular reactions between two water-soluble polymers, phospholipid polymer (PMBV) containing a phenylboronic acid unit and poly(vinyl alcohol) (PVA). Reversible covalent bonding between phenylboronic acid and the polyol provided the driving force for self-assembly. Poorly water-soluble PTX dissolves in PMBV aqueous solutions because PMBV is amphiphilic. Therefore, our multilayered hydrogel could be loaded with PTX at different locations to control the release profile and act as a drug reservoir. The amount of PTX incorporated in the hydrogel samples increased with the number of layers but was not directly proportional to the number of layers. However, as the step for making layers was repeated, the concentration of PTX in the PMBV layers increased. The different solubilities of PTX in PMBV and PVA aqueous solutions allow for the production of multilayered hydrogels loaded with PTX at different locations. In vitro experiments demonstrated that the l

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Author

Jiyeon Choi; Tomohiro Konno; Madoka Takai; Kazuhiko Ishihara

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0142-9612)

Published

2009

Language

EN

Field

Engineering (Physical Sciences)