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Can I read The 10-Year Effects of Intensive Lifestyle Intervention on Kidney Outcomes on EtoBox?
The 10-Year Effects of Intensive Lifestyle Intervention on Kidney Outcomes by Linda-Marie U. Lavenburg; Douglas E. Schaubel; Ariana M. Chao; Peter P. Reese; Jordana B. Cohen is a Medicine article available to read on EtoBox.
What is The 10-Year Effects of Intensive Lifestyle Intervention on Kidney Outcomes about?
## Rationale & Objective Limited data exist on longitudinal kidney outcomes after nonsurgical obesity treatments. We investigated the effects of intensive lifestyle intervention on kidney function over 10 years. ## Study Design Post hoc analysis of Action for Health in Diabetes (Look AHEAD) randomized controlled trial. ## Setting & Participants We studied 4,901 individuals with type 2 diabetes and body mass index of ≥25 kg/m^2^ enrolled in Look AHEAD (2001–2015). The original Look AHEAD trial excluded individuals with 4+ urine dipstick protein, serum creatinine level of >1.4 mg/dL (women), 1.5 mg/dL (men), or dialysis dependence. ## Exposures Intensive lifestyle intervention versus diabetes support and education (ie, usual care). ## Outcome Primary outcome was estimated glomerular filtration rate (eGFR, mL/min/1.73 m^2^) slope. Secondary outcomes were mean eGFR, slope, and mean urine albumin to creatinine ratio (UACR, mg/mg). ## Analytical Approach Linear mixed-effects models with random slopes and intercepts to evaluate the association between randomization arms and within-individual repeated measures of eGFR and UACR. We tested for effect modification by baseline eGFR. ## Results
Who reads The 10-Year Effects of Intensive Lifestyle Intervention on Kidney Outcomes?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Linda-Marie U. Lavenburg; Douglas E. Schaubel; Ariana M. Chao; Peter P. Reese; Jordana B. Cohen
- Publisher
- Elsevier
- Published
- 2024
- Language
- EN
- Field
- Medicine (Health Sciences)