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Abiotic Synthetic Antibody Inhibitor with Broad-Spectrum Neutralization and Antiviral Efficacy against Escaping SARS-CoV-2 Variants by Bingxue Li; Ya Zhao; Xuefan Wu; Haiyan Wu; Weicheng Tang; Xiaoyang Yu; Jianqiong Mou; Wenfeng Tan; Meilin Jin; Wei Li; Qiang Zhang; Mingming Liu is a scholarly article available to read on EtoBox.

What is Abiotic Synthetic Antibody Inhibitor with Broad-Spectrum Neutralization and Antiviral Efficacy against Escaping SARS-CoV-2 Variants about?

The rapid emergence and spread of vaccine/ antibody-escaping variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed serious challenges to our efforts in combating corona virus disease 2019 (COVID-19) pandemic. A potent and broad-spectrum neutralizing reagent against these escaping mutants is extremely important for the development of strategies for the prevention and treatment of SARS-CoV-2 infection. We herein report an abiotic synthetic antibody inhibitor as a potential anti-SARS-CoV-2 therapeutic agent. The inhibitor, Aphe-NP14, was selected from a synthetic hydrogel polymer nanoparticle library created by incorporating monomers with functionalities complementary to key residues of the SARS-CoV-2 spike glycoprotein receptor binding domain (RBD) involved in human angiotensin-converting enzyme 2 (ACE2) binding. It has high capacity, fast adsorption kinetics, strong affinity, and broad specificity in biologically relevant conditions to both the wild type and the current variants of concern, including Beta, Delta, and Omicron spike RBD. The Aphe-NP14 uptake of spike RBD results in strong blockage of spike RBD−ACE2 interaction and thus potent neutralizatio

Author

Bingxue Li; Ya Zhao; Xuefan Wu; Haiyan Wu; Weicheng Tang; Xiaoyang Yu; Jianqiong Mou; Wenfeng Tan; Meilin Jin; Wei Li; Qiang Zhang; Mingming Liu

Publisher

American Chemical Society (ACS)

Published

2023

Language

EN