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Angiopoietin 2 and hsCRP are associated with pulmonary hemodynamics and long-term mortality respectively in CTEPH—Results from a prospective discovery and validation biomarker study by Charaka M. Hadinnapola; Mark Southwood; Jules Hernández – Sánchez; Katherine Bunclark; Michael Newnham; Emilia M. Swietlik; John Cannon; Stephen D. Preston; Karen Sheares; Dolores Taboada; Nicholas Screaton; David P. Jenkins; Nicholas W. Morrell; Mark Toshner; Joanna Pepke-Zaba is a Medicine article available to read on EtoBox.

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INTRODUCTION: Chronic thromboembolic pulmonary hypertension (CTEPH) is an underdiagnosed disease of uncertain etiology. Altered endothelial homeostasis, defective angiogenesis and inflammation are implicated. Angiopoietin 2 (Ang2) impairs acute thrombus resolution and is associated with vasculopathy in idiopathic pulmonary arterial hypertension. METHODS: We assessed circulating proteins associated with these processes in serum from patients with CTEPH (n = 71) before and after pulmonary endarterectomy (PEA), chronic thromboembolic pulmonary disease without pulmonary hypertension (CTEPD, n = 9) and healthy controls (n = 20) using Luminex multiplex arrays. Comparisons between groups were made using multivariable rank regression models. Ang2 and high-sensitivity C-reactive protein (hsCRP) were measured in a larger validation dataset (CTEPH = 277, CTEPD = 26). Cox proportional hazards models were used to identify markers predictive of survival. RESULTS: In CTEPH patients, Ang2, interleukin (IL) 8, tumor necrosis factor a, and hsCRP were elevated compared to controls, while vascular endothelial growth factor (VEGF) c was lower (p < 0.05). Ang2 fell post-PEA (p < 0.05) and was associated

Who reads Angiopoietin 2 and hsCRP are associated with pulmonary hemodynamics and long-term mortality respectively in CTEPH—Results from a prospective discovery and validation biomarker study?

Author

Charaka M. Hadinnapola; Mark Southwood; Jules Hernández – Sánchez; Katherine Bunclark; Michael Newnham; Emilia M. Swietlik; John Cannon; Stephen D. Preston; Karen Sheares; Dolores Taboada; Nicholas Screaton; David P. Jenkins; Nicholas W. Morrell; Mark Toshner; Joanna Pepke-Zaba

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)