Can I read A sequence of immuno-chemotherapy with Rituximab, mobilization of in vivo purged stem cells, high-dose chemotherapy and autotransplant is an effective and non-toxic treatment for advanced follicular and mantle cell lymphoma on EtoBox?

A sequence of immuno-chemotherapy with Rituximab, mobilization of in vivo purged stem cells, high-dose chemotherapy and autotransplant is an effective and non-toxic treatment for advanced follicular and mantle cell lymphoma by M. Lazzarino; L. Arcaini; P. Bernasconi; E. P. Alessandrino; L. Gargantini; R. Cairoli; E. Orlandi; C. Astori; E. Brusamolino; G. Pagnucco; A. A. Colombo; S. Calatroni; I. Iacona; M. B. Regazzi; E. Morra is a Medicine article available to read on EtoBox.

What is A sequence of immuno-chemotherapy with Rituximab, mobilization of in vivo purged stem cells, high-dose chemotherapy and autotransplant is an effective and non-toxic treatment for advanced follicular and mantle cell lymphoma about?

**Summary.** Options for relapsed/refractory indolent lymphoma include chemotherapy, immunotherapy and high‐dose therapy with autologous support. The best combination of these approaches, however, is not defined. We treated 10 patients with relapsed/refractory follicular (__n__ = 7) or mantle cell lymphoma (__n__ = 3) using chemotherapy, immunotherapy, high‐dose therapy and autotransplant in a sequence of four phases, each designed to play a specific role in tumour eradication. After the debulking with VACOP‐B (doxorubicin, cyclophosphamide, etoposide, vincristine, prednisone, bleomycin) (phase 1), 9/10 patients responded but none achieved a molecular response. After the immuno‐chemotherapy phase, which combined Rituximab with vincristine and cyclophosphamide, seven patients were in complete response (CR) and three in good partial response (PR), and all those with a molecular marker of disease showed a disappearance of the signal from marrow and blood. Phase 3, which coupled high‐dose cytarabine with Rituximab, was effective in mobilizing an adequate number of progenitor cells that were polymerase chain reaction negative in all informative cases. Phase 4 consisted of high‐dose ther

Who reads A sequence of immuno-chemotherapy with Rituximab, mobilization of in vivo purged stem cells, high-dose chemotherapy and autotransplant is an effective and non-toxic treatment for advanced follicular and mantle cell lymphoma?

Author

M. Lazzarino; L. Arcaini; P. Bernasconi; E. P. Alessandrino; L. Gargantini; R. Cairoli; E. Orlandi; C. Astori; E. Brusamolino; G. Pagnucco; A. A. Colombo; S. Calatroni; I. Iacona; M. B. Regazzi; E. Morra

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)

Published

2002

Language

EN

Field

Medicine (Health Sciences)